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ACTIVATE
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Traducere în limba română
activate verb tranzitiv
1. (chim., biol.) a activa, a activiza; a accelera, a grăbi, a iuţi.
2. (fiz.) a face radioactiv.
3. (amer., mil.) a forma, a completa.
Exemple de propoziții și/sau fraze:
The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene.
(Melanoma Pathway, NCI Thesaurus/KEGG)
When GR is activated in visceral adipose tissue, it will increase the expression of lipoprotein lipase (LPL).
(Metabolic Syndrome Pathway, NCI Thesaurus/BIOCARTA)
They showed that TET1 activates a chemical switch - known as an epigenetic modification - on the ductal cell's DNA.
(Regeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease, University of Cambridge)
Meluadrine binds to and activates beta-2 adrenergic receptors of myometrial smooth muscle in the uterus, thereby activates adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP).
(Meluadrine, NCI Thesaurus)
Subsequently, the Fc component of the engineered antibody targets and binds to the CD64 receptor on the dendritic cells (DCs); upon processing by DCs, the cellular immune system may be activated to induce helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen.
(Melanoma TRP2 CTL Epitope Vaccine SCIB1, NCI Thesaurus)
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.
(MEK Inhibitor CI-1040, NCI Thesaurus)
When activated in adipose tissue, GR increases the level of visceral fat, induces insulin resistance and dyslipidemias that increase the risk of heart disease.
(Metabolic Syndrome Pathway, NCI Thesaurus/BIOCARTA)
Because the epigenetic switch activated by TET1 does not modify the genetic sequence of the cell, but the mechanism by which the genes are expressed, it represents a target that could be modified by drugs.
(Regeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease, University of Cambridge)
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