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CATHEPSIN

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cathepsin substantiv

(biol., chim.) catepsină.

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This allele, which encodes cathepsin L protein, is involved in lysosomal protein degradation.

(CTSL1 wt Allele, NCI Thesaurus)

This allele, which encodes cathepsin S protein, plays a role in antigen processing.

(CTSS wt Allele, NCI Thesaurus)

This allele, which encodes cathepsin K protein, plays a role in the regulation of both proteolysis and osteoclastic bone resorption.

(CTSK wt Allele, NCI Thesaurus)

This allele, which encodes cathepsin H protein, plays a role in protein degradation within lysosomes.

(CTSH wt Allele, NCI Thesaurus)

This allele, which encodes cathepsin G protein, is involved in protein processing and degradation.

(CTSG wt Allele, NCI Thesaurus)

This allele, which encodes cathepsin Z protein, plays a role in the release of C-terminal amino acids from lysosomal proteins.

(CTSZ wt Allele, NCI Thesaurus)

This protein plays a role in the modulation of cathepsin B activity.

(Cystatin-M, NCI Thesaurus)

A rare autosomal recessive inherited disorder caused by mutations in the cathepsin C gene.

(Papillon-Lefevre Syndrome, NCI Thesaurus)

Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.

(Odanacatib, NCI Thesaurus)

Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.

(Cathepsin, NCI Thesaurus)

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