Editura Global Info / Dicţionar englez-român

CLEAVAGE

Pronunție (USA):

(GB):

Traducere în limba română

cleavage substantiv

1. crăpare, despicare.

2. crăpătură, despicătură, fisură.

3. (fig.) diferenţă, deosebire, dezacord; neînţelegere; dezbinare; fisură;

cleavage in regard to views deosebire de vederi, păreri împărţite;

cleavage of society into classes împărţirea societaţii în clase.

4. (geol., mineral.) clivaj; despicare / desfacere a rocilor; stratificare.

5. (biol.) diviziune celulară; diviziune mitotică.

6. divizibilitate naturală.

7. scindare, spintecare, despicare.

8. despicătura sânilor; decolteu.

 Exemple de propoziții și/sau fraze: 

In fresh brain lysates, addition of calcium can stimulate cleavage of p35 to p25.

(Alzheimer's Disease Pathway BioCarta, NCI Thesaurus/BIOCARTA)

Activation of Notch receptors by DLL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated to the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development.

(Anti-DLL4 Monoclonal Antibody MEDI0639, NCI Thesaurus)

Expressed in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney by human PLAB Gene (BMP/TGF-Beta Family), 308-aa 34-kDa (precursor) Placental TGF-Beta is processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids.

(Placental TGF-Beta, NCI Thesaurus)

After internalization and enzymatic cleavage of the immunoconjugate within the tumor cell cytosol, free MMAF binds to tubulin and inhibits its polymerization, which may result in G2/M phase arrest and tumor cell apoptosis.

(Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547, NCI Thesaurus)

Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks.

(Amsacrine Lactate, NCI Thesaurus)

After internalization and enzymatic cleavage of the immunoconjugate within the tumor cell cytosol, free MMAF binds to tubulin and inhibits its polymerization, which may result in G2/M phase arrest and tumor cell apoptosis. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness.

(Anti-5T4 Antibody-Drug Conjugate PF-06263507, NCI Thesaurus)

A site on a protein that is a target for enzymatic cleavage, where the residue on the amino terminal side of the cleavage site is a basic amino acid that is not adjacent to other basic amino acids.

(Monobasic Proteolytic Cleavage Site, NCI Thesaurus)

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