Editura Global Info / Dicţionar englez-român

COMPETITIVE

Pronunție (USA):

(GB):

Traducere în limba română

competitive adi.

competitiv, cu caracter de întrecere / de concurs.

 Exemple de propoziții și/sau fraze: 

Your current project will elevate your profile in your firm, as well as in your industry, and help you to get an important promotion or an offer from a competitive firm.

(AstrologyZone.com, de Susan Miller)

The protein encoded by the p16INK4a gene inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6.

(Non-Small Cell Lung Cancer Pathway, NCI Thesaurus/KEGG)

AKT inhibitor ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway.

(AKT Inhibitor ARQ 092, NCI Thesaurus)

Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations.

(PI3K Family Kinase Inhibitor XL147, NCI Thesaurus)

PI3K inhibitor GDC-0941 selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway; inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations may result.

(PI3K Inhibitor GDC-0941 Bismesylate, NCI Thesaurus)

PI3K inhibitor BKM120 specifically inhibits class I PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway.

(PI3K Inhibitor BKM120, NCI Thesaurus)

AKT1/2 inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway.

(AKT 1/2 Inhibitor BAY1125976, NCI Thesaurus)

A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor MK2461 preferentially inhibits activated c-Met in an ATP-competitive manner, thereby inhibiting its tyrosine kinase activity, which may inhibit c-Met signaling and result in cell growth inhibition in tumors that overexpress c-Met. c-Met, encoding the hepatocyte growth factor receptor (HGFR) tyrosine kinase, plays an important role in tumor cell proliferation and has been shown to be overexpressed or mutated in a variety of cancers.

(c-Met Inhibitor MK2461, NCI Thesaurus)

AT13148 inhibits, in an ATP-competitive manner, the enzymatic activity of two AGC kinases, protein kinase B (PKB or AKT) and p70S6K which play key roles in the PI3K/PKB/mTOR signaling pathway.

(Multi-AGC Kinase Inhibitor AT13148, NCI Thesaurus)

Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

(Akt Inhibitor MK2206, NCI Thesaurus)

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