Editura Global Info / Dicţionar englez-român

CONFORMATION

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(GB):

Traducere în limba română

conformation substantiv

1. conformaţie, formă.

2. concordanţă, conformare, potrivire.

 Exemple de propoziții și/sau fraze: 

This allele, which encodes caveolin-2 protein, plays a role in caveolae conformation.

(CAV2 wt Allele, NCI Thesaurus)

This allele, which encodes collagen alpha-6 (IV) chain protein, is involved in the regulation of the conformation of the basement membrane.

(COL4A6 wt Allele, NCI Thesaurus)

This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I expression or alter its conformation.

(Natural Killer Cell-Mediated Cytotoxicity Pathway, NCI Thesaurus/KEGG)

Overexpression of hTid-1 represses transcriptional activation by interferon-gamma and Hsp70 dissociates from these proteins when interferon is added to cells, suggesting that Hsp70 holds Jak2 in an inactive conformation prior to ligand activation, and is released in the presence of agonist to allow the activation of Jak-2 and downstream pathways. hTid-1 and Hsp-70 interact with other signaling proteins as well.

(Interferon Signaling Modulation Pathway, NCI Thesaurus/BIOCARTA)

Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells.

(Nilotinib, NCI Thesaurus)

Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and subsequently, the inhibition of mitosis and tumor cell death.

(Noscapine Hydrochloride, NCI Thesaurus)

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