Editura Global Info / Dicţionar englez-român

DELETION

Pronunție (USA):

(GB):

Traducere în limba română

deletion substantiv

ştergere, radere.

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Additionally, deletion of ICP47 causes increased expression of the HSV US11 gene and allows US11 to be expressed as an immediate early and not a late gene.

(Oncolytic Herpes Simplex Virus-1-encoding GM-CSF, NCI Thesaurus)

Examining the metabolic consequences of coactivator deletion, Src-1 and Tif2 specifically alter PPAR-gamma signaling.

(Obesity and Thermogenesis Pathway, NCI Thesaurus/BIOCARTA)

Deletions in the gene are associated with hyper-IgM immunodeficiency type 3.

(CD40 wt Allele, NCI Thesaurus)

Deletion mutation of the gene is associated with various neoplasms.

(CCSER1 wt Allele, NCI Thesaurus)

EGFRvIII, a deletion mutation of exons 2-7 in the epidermal growth factor receptor gene, is overexpressed by a variety of cancers, including glioblastoma multiforme, non-small lung carcinoma, and breast carcinoma.

(Anti-EGFRvIII Antibody Drug Conjugate AMG 595, NCI Thesaurus)

These FSPs all have one-base deletions.

(AIM2(-1)/HT001(-1)/TAF1B(-1) Frameshift Peptide Vaccine, NCI Thesaurus)

A fusion gene that results from an intrachromosomal deletion of the pseudoautosomal region 1of Xp22.3 and Yp11.3 which fuses the noncoding exon 1 of the P2RY8 gene to the entire coding region of the CRLF2 gene.

(P2RY8/CRLF2 Fusion Gene, NCI Thesaurus)

MoAb ABT-806 targets the EGFR deletion variant, de2-7 EGFR as well as wild-type EGFR expressed in cells overexpressing the receptor, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization result in an inhibition in signal transduction and anti-proliferative effects.

(Anti-EGFR Monoclonal Antibody ABT-806, NCI Thesaurus)

While the deletion of both LRRK1 and LRRK2 did not affect overall brain size or cells in such areas of the brain as the cerebral cortex and cerebellum, the mice showed other significant effects such as a decrease in body weight and a lifespan of only 15 to 16 months.

(Scientists find a role for Parkinson’s gene in the brain, Editura Global Info)

BH4 is present only in the amino-terminal regions of pro-survival family bcl-2 members and is essential for the anti-apoptotic function, although deletion of BH4 does not necessarily impair the ability of BH4-containing proteins to bind to a variety of other bcl-2-related proteins.

(BH4 Domain, NCI Thesaurus)

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