Editura Global Info / Dicţionar englez-român

DIFFERENTIATION

Pronunție (USA):

(GB):

Traducere în limba română

differentiation substantiv

diferenţiere, deosebire, distincţie.

 Exemple de propoziții și/sau fraze: 

This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type.

(Metaplastic carcinoma, NCI Thesaurus)

Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others.

(Mocetinostat, NCI Thesaurus)

Part of the reason why those cells are defective in the differentiation program, which would mean that they would stop dividing, is that the β-catenin complex is being degraded in those cells because of an anomaly in the signaling pathway that controls that.

(New Genes Found Responsible for Regulating Muscle Cells, Editura Global Info)

A cancer vaccine consisting of a peptide derived from the melanocyte differentiation antigen Melan-A (or MART-1) and the human leukocyte antigen HLA-DP4-restricted human melanoma antigen 3 (MAGE-3.DP4), with potential immunostimulating and antineoplastic activities.

(Melan-A/MAGE-3.DP4 Peptide Vaccine, NCI Thesaurus)

A unique set of genes has been uncovered by York University scientists responsible for playing a role in muscle cellular gene expression and differentiation which could lead to new therapeutic targets to prevent the spread of muscle cancer.

(New Genes Found Responsible for Regulating Muscle Cells, Editura Global Info)

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