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DISASSEMBLY

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Traducere în limba română

disassembly substantiv

demontare (a unei maşini etc.); descompunere; dezasamblare.

 Exemple de propoziții și/sau fraze: 

Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division.

(Paclitaxel, NCI Thesaurus)

Paclitaxel binds to and stabilizes tubulin thereby inhibiting the disassembly of microtubules, resulting in the inhibition of cell division.

(Paclitaxel Ceribate, NCI Thesaurus)

Paclitaxel, the active ingredient in cationic liposome-encapsulated paclitaxel, binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis and cellular proliferation, and apoptosis.

(Cationic Liposome-Encapsulated Paclitaxel, NCI Thesaurus)

The monoclonal antibody portion of anti-CD33 monoclonal antibody-DM4 conjugate AVE9633 specifically binds to the cell surface antigen CD33 expressed on myeloid leukemia cells; upon internalization, the DM4 moiety is released, binds tubulin, and disrupts microtubule assembly/disassembly dynamics, resulting in the inhibition of cell division and cell growth in myeloid leukemia cells that express CD33.

(Anti-CD33 Monoclonal Antibody-DM4 Conjugate AVE9633, NCI Thesaurus)

Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CD19-expressing tumor cells.

(Anti-CD19-DM4 Immunoconjugate SAR3419, NCI Thesaurus)

Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CA6-expressing tumor cells.

(Anti-CA6-DM4 Immunoconjugate SAR566658, NCI Thesaurus)

Integrin-targeted immunoconjugate IMGN388 binds to tumor cell surface integrins; upon internalization, the DM4 moiety is released from the immunoconjugate, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in inhibition of cell division and cell growth of integrin-expressing tumor cells.

(Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388, NCI Thesaurus)

The monoclonal antibody moiety of anti-mesothelin antibody-drug conjugate BAY 94-9343 targets and binds to the tumor associated antigen mesothelin; upon internalization, the DM4 moiety binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of mesothelin-expressing tumor cells.

(Anti-mesothelin Antibody-Drug Conjugate BAY 94-9343, NCI Thesaurus)

Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division.

(DHA-paclitaxel, NCI Thesaurus)

Chaperone Protein Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction by cellular proteins that mediate assembly/disassembly, stabilization, and transmembrane translocation of other polypeptides or complexes, but which are not components of those final structures.

(Chaperone Protein Interaction Process, NCI Thesaurus)

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