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GUANINE

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(GB):

Traducere în limba română

guanine substantiv

(chim.) guanină.

 Exemple de propoziții și/sau fraze: 

RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.

(p21 H-Ras Protein, NCI Thesaurus)

This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to the C-terminal RGS-like domain of the Rho guanine nucleotide exchange factor 12 protein.

(MLL/ARHGEF12 Fusion Protein, NCI Thesaurus)

The resulting bioactive mono-alkyltriazene species are capable of alkylating nucleophilic residues in the immediate vicinity such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA cross-links and trigger apoptosis.

(Mitozolomide, NCI Thesaurus)

IMPDH catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, and treatment with merimepodib reduces the intracellular guanine nucleotide levels that are required for RNA and DNA synthesis, resulting in antiproliferative and antiviral effect.

(Merimepodib, NCI Thesaurus)

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