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INHIBITOR

Pronunție (USA):

(GB):

Traducere în limba română

inhibitor substantiv

1. (tehn.) dispozitiv de încetintie.

2. (constr., fot. etc.) încetinitor,

3. (tehn.) dispozitiv de frânare.

4. (agr., chim.) inhibitor.

 Exemple de propoziții și/sau fraze: 

Also called PARP-1 inhibitor ABT-888 and veliparib.

(ABT-888, NCI Dictionary)

In addition, some immunotherapy treatments, such as CAR T cells and immune checkpoint inhibitors, are limited by the life span of T cells.

(Harnessing T-cell “stemness” could enhance cancer immunotherapy, National Institutes of Health)

All 3 inhibitors blocked the effects of the mutations on patient cell samples in the laboratory.

(Gene linked to rare inflammatory disease in children, NIH)

In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme.

(Acridine, NCI Thesaurus)

MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.

(MET Tyrosine Kinase Inhibitor BMS-777607, NCI Thesaurus)

MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)

MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor TAK-733, NCI Thesaurus)

MEK inhibitor WX-554 selectively binds to and inhibits the activity of MEK, thereby preventing the activation of MEK-dependent effector proteins including some transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor WX-554, NCI Thesaurus)

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