Editura Global Info / Dicţionar englez-român

INHIBITORY

Pronunție (USA):

(GB):

Traducere în limba română

inhibitory adjectiv

1. care opreşte / interzice, prohibitiv.

2. (fiziol.) inhibitor.

 Exemple de propoziții și/sau fraze: 

In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.

(Nonsteroidal Antiinflammatory Drug, NLM, Medical Subject Headings)

At the cellular level, these mice showed a marked increase in both excitatory and inhibitory currents, resulting in normal neuron activity.

(Self-tuning neurons promote resilience to stress, depression, NIH)

The fact that the absence of LRRK leads to the death of dopamine-containing neurons suggests that the use of inhibitory drugs as a treatment for Parkinson’s disease might not be the best approach.

(Scientists find a role for Parkinson’s gene in the brain, Editura Global Info)

PD-1 is an inhibitory receptor belonging to the B7-receptor family that is expressed on lymphocytes and myeloid cells; its ligands, PD-1L1 and PD-1L2, are expressed not only by hematopoietic cells but also by cells in non-lymphoid tissues.

(Pidilizumab, NCI Thesaurus)

This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.

(Mometasone furoate, NCI Thesaurus)

Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues.

(Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine, NCI Thesaurus)

Anti-CTLA4 MoAb RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes.

(Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine, NCI Thesaurus)

Compared to other anti-HER2 monoclonal antibodies, the Fc domain of MGAH22 is optimized with increased binding to the activating Fcgamma receptor IIIA (CD16A), expressed on cells such as natural killer (NK) cells and macrophages, thereby mediating an enhanced ADCC; the Fc domain also shows decreased binding to the inhibitory Fcgamma receptor IIB (CD32B).

(Anti-HER2 Monoclonal Antibody MGAH22, NCI Thesaurus)

This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I expression or alter its conformation.

(Natural Killer Cell-Mediated Cytotoxicity Pathway, NCI Thesaurus/KEGG)

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