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INTERCALATE

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Traducere în limba română

intercalate verb tranzitiv

a intercala; a interpola.

 Exemple de propoziții și/sau fraze: 

It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.

(Amonafide, NCI Dictionary)

Amustaline binds to, intercalates and crosslinks DNA and RNA.

(Amustaline, NCI Thesaurus)

Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.

(Anthracycline Analogue GPX-150, NCI Thesaurus)

These agents display potent antitumor properties due to their ability to intercalate into DNA and interfere with the function of both the topoisomerase I and II enzymes, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.

(Aclacinomycin Antitumor Antibiotic, NCI Thesaurus)

Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks.

(Amsacrine Lactate, NCI Thesaurus)

The milatuzumab moiety of this ADC selectively binds to CD74 on tumor cell surfaces; upon internalization, the doxorubicin moiety is released, where it intercalates between base pairs in the DNA helix and inhibits topoisomerase II, thereby preventing DNA replication and increasing double-strand breakage.

(Milatuzumab-Doxorubicin Antibody-Drug Conjugate, NCI Thesaurus)

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