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INTERCONVERSION

Traducere în limba română

interconversion substantiv

transformare / convertire unul în altul, convertire reciprocă.

 Exemple de propoziții și/sau fraze: 

Any substance that inhibits hydroxysteroid dehydrogenase, an enzyme that catalyzes the interconversion of hydroxyl and carboxyl groups on steroids, leading to activation or deactivation of the steroid molecule.

(Hydroxysteroid Dehydrogenase Inhibitor, NCI Thesaurus)

The Gly-rich NAD-Binding Domain (often N-terminal) is often found in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion).

(NAD-Binding Domain, NCI Thesaurus)

As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors.

(Methazolamide, NCI Thesaurus)

Upon oral administration, mercaptopurine is metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) to its active metabolite 6-thioinosine monophosphate (TIMP); TIMP inhibits nucleotide interconversions and de novo purine ribonucleotide synthesis, which both blocks the formation of purine nucleotides and inhibits DNA synthesis.

(Mercaptopurine Oral Suspension, NCI Thesaurus)

Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis.

(Mercaptopurine, NCI Thesaurus)

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