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KILLER
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Traducere în limba română
killer substantiv
1. ucigaş, asasin.
2. (iht.) delfin cu aripă ca sabia (Orcinus orca).
3. persoană grozavă, om de succes.
4. lucru grozav (ex. carte de succes).
Exemple de propoziții și/sau fraze:
"You can never cure a chicken-killer."
(White Fang, de Jack London)
These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as KILLER CELLS (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody.
(Natural killer cell, NLM, Medical Subject Headings)
Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation.
(Natural Killer Cell-Mediated Cytotoxicity Pathway, NCI Thesaurus/KEGG)
In nutritional studies, so far much of the research has been on the big killers such as heart diseases, stroke and cancer, but now we're starting to see data for other diseases, said study co-author Dagfinn Aune from the School of Public Health at Imperial.
(Daily Handful of Nuts Reduces Disease Risk, VOA)
IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells, inducing the secretion of interferon-gamma and inducing a cytotoxic T lymphocyte response against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.
(Adenoviral Transduced hIL-12-expressing Autologous Dendritic Cells INXN-3001 Plus Activator Ligand INXN-1001, NCI Thesaurus)
Compared to other anti-HER2 monoclonal antibodies, the Fc domain of MGAH22 is optimized with increased binding to the activating Fcgamma receptor IIIA (CD16A), expressed on cells such as natural killer (NK) cells and macrophages, thereby mediating an enhanced ADCC; the Fc domain also shows decreased binding to the inhibitory Fcgamma receptor IIB (CD32B).
(Anti-HER2 Monoclonal Antibody MGAH22, NCI Thesaurus)
Anti-CD30/CD16A monoclonal antibody AFM13 binds to the CD16A expressed on natural killer (NK) cells with two of its binding sites and to CD30 on CD30-expressing tumor cells with the other two binding sites, thereby selectively cross-linking tumor and NK cells.
(Anti-CD30/CD16A Monoclonal Antibody AFM13, NCI Thesaurus)
IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.
(Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001, NCI Thesaurus)
In addition, binding of the IgG1 moiety of this agent to the Fc gamma receptor on the surface of natural killer (NK)cells may bridge NK cells and target T lymphocytes, initiating NK cell-mediated apoptosis of T lymphocytes.
(Alefacept, NCI Thesaurus)
Allogeneic natural killer (NK) cells transduced with an mRNA expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities.
(Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells, NCI Thesaurus)
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