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LEWIS

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lewis substantiv

(tehn.) vârtej (pentru ridicarea blocurilor mari de piatră).

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E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.

(E-Selectin, NCI Thesaurus)

In 111 CMD-193 binds to Lewis Y antigen-expressing tumor cells via its antibody moiety and is internalized; subsequently, the calicheamicin moiety binds to the minor groove of tumor cell DNA, causing double-strand DNA breaks, the inhibition of DNA synthesis, and apoptosis.

(Indium In 111-CMD-193, NCI Thesaurus)

A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells.

(LMB-7 immunotoxin, NCI Thesaurus)

SYN Sialyl-Lewis X defect.

(Leukocyte Adhesion Deficiency Type 2, NCI Thesaurus)

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