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PROCESSING
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processing substantiv
(tehn.) prelucrare (în special chimică sau termică).
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This allele, which encodes prolyl 4-hydroxylase subunit alpha-2 protein, plays a role in procollagen processing.
(P4HA2 wt Allele, NCI Thesaurus)
HSP70 associates with antigenic peptides, transporting them into antigen presenting cells (APC) for processing.
(Autologous Heat-Shock Protein 70 Peptide Vaccine AG-858, NCI Thesaurus)
Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space.
(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)
Although there is much left to explore, the identification of this direct neural pathway may help explain the role of this circuit in disorders that involve reward-related and social-processing systems, such as addiction, autism, and schizophrenia, and may point to future targets for intervention and symptom management.
(New Findings Reveal Surprising Role of the Cerebellum in Reward and Social Behaviors, National Institutes of Health)
Adults with high prenatal exposure to methylmercury, which mainly comes from maternal consumption of fish with high mercury levels, did not experience the faster cognitive processing and better short term memory benefits of exercise that were seen in those with low prenatal methylmercury exposures.
(Brain benefits of aerobic exercise lost to mercury exposure, NIH)
The proteolytic processing of Notch resembles in several ways the proteolytic processing of amyloid precursor protein (APP) that is implicated in plaque formation in Alzheimer's disease, with TACE and Presenilin-1 implicated in proteolytic processing of both Notch and APP.
(Notch Proteolysis and Signaling Pathway, NCI Thesaurus/BIOCARTA)
Subsequently, the Fc component of the engineered antibody targets and binds to the CD64 receptor on the dendritic cells (DCs); upon processing by DCs, the cellular immune system may be activated to induce helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen.
(Melanoma TRP2 CTL Epitope Vaccine SCIB1, NCI Thesaurus)
The Molecular Diagnostics Laboratory Shared Resource provides support to Cancer Center investigators with specimen processing and tracking, DNA sequencing, microsatellite and SNP analyses, quantitative PCR, protein analysis as well as other services, to analyze genes and genes products that are, or may be, involved in the etiology of cancer.
(Molecular Diagnostics Laboratory Shared Resource, NCI Thesaurus)
NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation.
(Non-Homologous End-Joining Pathway, NCI Thesaurus/KEGG)