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    RETINAL

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    retinal adjectiv

    (anat.) al retinei, de retină.

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    National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice.

    (Retinal prion disease study redefines role for brain cells, National Institutes of Health)

    Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor cells expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas.

    (gp100-Reactive Autologous Tumor Infiltrating Lymphocyte, NCI Thesaurus)

    The researchers injured the mice retinas with a toxin that causes cell death in retinal ganglion cells and interneurons, another type of retinal cell whose job it is to transmit signals from photoreceptors to the brain.

    (Researchers unlock regenerative potential of cells in the mouse retina, National Institutes of Health)

    Vaccination with gp100:154-162 peptide may enhance tumor-specific T-cell immunity. gp100 antigen is a self-antigen expressed by melanocytes, pigmented retinal cells, and most melanoma lesions and is recognized via class I and II HLA-restricted mechanisms.

    (gp100:154-162 Peptide Vaccine, NCI Thesaurus)

    Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor sites expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas.

    (gp100-Reactive Autologous Peripheral Blood Lymphocyte, NCI Thesaurus)

    Vaccination with gp100:614-622 peptide may stimulate a cytotoxic T-cell immune response against tumor cells that express this antigen, resulting in decreased tumor growth and cell lysis. gp100 antigen is a self-antigen expressed by melanocytes, pigmented retinal cells and most melanoma lesions and recognized via class I and II HLA-restricted mechanisms.

    (gp100:614-622 Peptide, NCI Thesaurus)




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