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TOXICITY
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Traducere în limba română
toxicity substantiv
toxicitate.
Exemple de propoziții și/sau fraze:
The group evaluated the effects — including toxicity — of metarrestin in pancreatic cancer mouse models.
(Scientists develop potential new approach to stop cancer metastasis, National Institutes of Health)
The thiolytic environment and upregulated expression of thioredoxins at the tumor site allow for the activation and release of mitomycin C. This prodrug formulation allows for greater circulation time, less systemic toxicity and increased accumulation of mitomycin C at the tumor site.
(Pegylated Liposomal Mitomycin C Lipid-based Prodrug, NCI Thesaurus)
By changing different components of the MOF structure, researchers can create MOFs with different pore sizes, stabilities and toxicities, enabling them to design structures that can carry molecules such as siRNAs into cells without harmful side effects.
(Nanoparticles used to transport anti-cancer agent to cells, University of Cambridge)
Upon infusion, allogeneic CD19-specific CAR-modified CD8+ central memory-derived virus-specific T cells directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which may eventually result in tumor cell lysis.
(Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells, NCI Thesaurus)
Pulmonary toxicity may be dose-limiting.
(AFP464, NCI Thesaurus)
In comparison to cisplatin and other platinum-based compounds, treatment with BP-C1 allows for less platinum administration, which reduces platinum-associated systemic toxicity and side effects, and enhances the safety profile while maintaining or improving its efficacy.
(BP-Cx1-Platinum Complex BP-C1, NCI Thesaurus)
Introduction of these transfected autologous PBSCs back to the patient, may stimulate the expression of the O6 BG resistant mutant MGMT protein, which when used in combination with O6-alkylating drugs could protect the hematopoietic system against the hematopoietic toxicity of chemotherapeutic agents.
(MSCV (MGMTP140K) Retroviral Vector-Transduced CD34+ Autologous PBSC, NCI Thesaurus)
A modification of the standard method of allogeneic hematopoietic stem cell transplantation developed to allow for the therapy to be extended to a patient population that is unable to tolerate treatment with the conventional procedure due to its toxicity.
(Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation, NCI Thesaurus)
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