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ZIPPER

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zipper substantiv

fermoar.

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This protein is comprised of the N-terminal leucine zipper of the coiled-coil domain-containing protein 6 fused to almost the entire C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase receptor Ret protein, including the tyrosine kinase domain.

(CCDC6/RET Fusion Protein, NCI Thesaurus)

This protein is comprised of the N-terminal leucine zipper of the coiled-coil domain-containing protein 6 fused to the C-terminal transmembrane and cytoplasmic domains of the beta-type platelet-derived growth factor receptor protein, including the protein kinase domain.

(CCDC6/PDGFRB Fusion Protein, NCI Thesaurus)

FOS Family Genes encode nuclear leucine zipper FOS Family Proteins (FOS, FOSB, FOSL1, and FOSL2) that can dimerize with JUN Family proteins and bind DNA as the AP-1 transcription factor complex to regulate transcription in cell proliferation, differentiation, and transformation.

(FOS Family Gene, NCI Thesaurus)

This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to the C-terminal proline-rich region and ubiquitin-binding leucine zipper domain of the E3 ubiquitin-protein ligase CBL protein.

(MLL/CBL Fusion Protein, NCI Thesaurus)

This protein is comprised of the N-terminal half of the lipoma-preferred partner protein, including the proline-rich region and leucine zipper motifs, and the first LIM domain, fused with the C-terminal portion of the histone-lysine N-methyltransferase MLL protein.

(LPP/MLL Fusion Protein, NCI Thesaurus)

Encoded by JUN Family Genes, nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA-binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation.

(JUN Family Protein, NCI Thesaurus)

JUN Family Genes encode nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) that can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation.

(JUN Family Gene, NCI Thesaurus)

This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to the C-terminal leucine zipper domain of protein AF-10.

(MLL/MLLT10 Fusion Protein, NCI Thesaurus)

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